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Chick chorioallantoic membrane assays have confirmed pro-angiogenic activity, with GHK-Cu treatment producing 40-60% increases in vascular density within developing membranes

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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

Oxidative stress impairs serotonin signaling by diverting tryptophan to the kynurenine pathway, damaging synthesis enzymes like TPH (tryptophan hydroxylase), and disrupting ATP-dependent neurotransmitter release
