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These targets represent the rationale for interventions aiming to modulate aberrant bone remodeling, suppress catabolic cytokine signaling, restore anabolic growth-factor balance or selectively eliminate senescent cells, thereby shifting treatment goals toward true disease modification

Striking while the iron is hot: iron metabolism and ferroptosis in neurodegeneration

The hydrochloric acid regenerant is introduced from the bottom of the tank to regenerate the lower layer of cation resins

Taken together, these data indicated a direct correlation between lipid peroxidation and neurodegeneration, with the oxidized phospholipids suggestive of ferroptosis