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The neurological aspects of the disease are thought to arise from the accumulation of methylmalonyl- CoA due to the requirement of B 12 as a cofactor to the enzyme methylmalonyl-CoA mutase

Accordingly, EAE is most predictive for immunomodulatory and immuneCNS trafficking mechanisms, whereas remyelination-specific processes are often obscured by inflammation severity and axonal injury

10.4414/smw.2017.14421 [DOI] [PubMed] 31.Orhan Kili B, Kili S, ahin Erolu E et al (2021) Sublingual methylcobalamin treatment is as effective as intramuscular and peroral cyanocobalamin in children age 03 years

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