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It effectively neutralizes highly reactive radicals, such as OH and ONOO , while sparing normally physiologically active free radicals like O 2 , nitric oxide (NO), and H 2 O 2

However, this pilot trial did not match baseline cytokine levels between the pharmacotherapy conditions nor report any changes in depression levels at the end of treatment, hence the results may not be related to bipolar depression symptomology

5 DMF is taken orally and, following ingestion, is converted by gut esterases to monomethylfumarate (MMF), which is hydrolysed to fumaric acid and metabolised via the citric acid cycle