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doi: 10.3389/fphar.2021.716332

Although there is growing evidence supporting the use of curcumin, it should be noted that most studies have been conducted over short periods, typically involve small sample sizes, and curcumin is consistently administered in combination with DMARDs and at variable doses [6062]

Upregulation and release of S100 to the extracellular matrix could also initiate interaction with RAGE that eventually activates NF-B, inducing the production of pro-inflammatory cytokines and migration of neutrophils, monocytes, and macrophages (Xia et al., 2018)

Cells (510 5 10 6 cells/mL) washed twice in PBS, were incubated for 1h, in the dark, with FITC-labelled anti-CD71 (MEM-75, Thermo Fisher) and FITC-labelled mouse anti-human CD11b antibody (clone ICRF44