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Research Applications in Preclinical Research and Animal Models Much of what is currently known about peptide biology originates from preclinical models

, 53 using claudin-2-null mice, suggest that the loss of claudin-2 in colonic epithelium enhances susceptibility to the DSS-colitis complemented these findings

Phase I detoxification involves the cytochrome P450 enzyme system, which breaks down fat-soluble toxinssuch as pharmaceutical medications, heavy metals, mold mycotoxins, and metabolic wasteinto intermediate compounds

Redox in redux: Emergent roles for glutathione S-transferase P (GSTP) in regulation of cell signaling and S-glutathionylation