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However, mandatory fortification coupled with personal consumption of folic acid-containing supplements exposes a significant proportion of such populations to amounts of folic acid well above the recommended upper tolerable intake level established by the Institute of Medicine (77)

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Plant Physiol 136:24752482 Song WY, Choi KS, Kim DY, Geisler M, Park J, Vincenzetti V, Schellenberg M, Kim SH, Lim YP, Noh EW, Lee Y, Martinoia E (2010) ArabidopsisPCR2 is a zinc exporter involved in both zinc extrusion and long-distance zinc transport

Prior to targeted vasodilator therapy, supportive therapy was only available for symptom control, such as diuretics for fluid overload and oxygen to treat hypoxemia