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constructed an anti-HER2 dual-payload ADC carrying both MMAE and MMAF toxins, which achieved complete remission in breast cancer xenograft models with low HER2 expression and resistance to traditional T-DM1, significantly outperforming the efficacy of either single-payload ADC [139]

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In the redox reaction, the copper(II) metal center oxidizes the superoxide molecule to dioxygen, while the copper(II) metal center is reduced to copper(I)

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