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Among the PAHs, benzo[a]pyrene is one of the most extensively studied carcinogens, commonly found in cigarette smoke, vehicle exhaust, and industrial emissions

Whether or not the potential confounders were removed, the MR analysis of the 2 showed no significant statistical differences

Moreover, this condition leads to a low level of intrinsic factor, a protein that prevents vitamin B12 deficiency

Excess ROS leads to increased mitochondrial membrane permeability, impaired mitochondrial redox status, respiratory chain damage, and potassium ion efflux, ultimately leading to an irreversible cascade amplification reaction (Marullo et al., 2013)