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however, there is reasonable agreement that with aging comes the increased likelihood of compromised innate immunity, oxidative stress-induced damage, infection and neuroinflammation accompanied by microgliosis [2,3,39-42]

[DOI] [PMC free article] [PubMed] [Google Scholar] 249.Brahmachari S., Ge P., Lee S.H., Kim D., Karuppagounder S.S., Kumar M., Mao X., Shin J.H., Lee Y., Pletnikova O., et al

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Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses