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Epithelial cells are connected through tight junctions, gap junctions, adhesive junctions and desmosomes, which prevent toxic macromolecules and microbial organisms from passing through and play an innate defense role (Hansson, 2019)

Other tests that may be performed initially include levels of follicle-stimulating hormone (FSH), prolactin, DHT, DHEA-S (a weak androgen and precursor for other steroid hormones), estradiol (E2, the most active estrogen), hemoglobin, hematocrit, albumin, and sex hormone-binding globulin (SHBG, a steroid hormone-carrying protein)

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