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J Neurosci 26:334556, PMID: 16554485 Barger SW, Goodwin ME, Porter MM, Beggs ML (2007) Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation

122 Peroxynitrite stimulates TLR4 and NF-B activation and cytokines (release of TNF-, IL-1, and IL-8) 123 , and NOX-induced ROS play a role in inflammasome activation, such as the NLRP3 inflammasome, which drives caspase activity and cytokine production to enhance immune cell recruitment and function

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Therefore, three pathways can be followed to reach to the brain interstitial fluids including receptor-accelerated transfer, lipid-induced free diffusion and carrier-triggered transport systems [151, 152]