patent tim guilford glutathione CooP | Glioblastoma-Targeting Nonapeptide Phytotherapy Research | Medicinal Chemistry

Our results in TBI mice showed that GFAP levels peaked at 24 h in both vehicle and CAQK-treated groups, indicating comparable severity of TBI

For instance, it is demonstrated that GSTA played an essential role in the detoxification of chlorambucil via catalyzing the GSH conjugation reaction of this alkylating reagent [104]

It has been reported that epithelial-specific deletion of the focal adhesion kinase (FAK), which is necessary for cell migration, leads to epithelial cell apoptosis and enhanced bleomycin injury, while enhancement of the Notch signaling pathway leads to functional impairment of Tp63-expressing stem cells in the bronchiolar epithelium

In U937 and HepG2 cells, blocking GSH efflux prevented puromycin-induced apoptosis (Ghibelli et al, 1998), suggesting depletion of GSH played an important role in initiating apoptosis in some cell types