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doi: 10.2147/IJN.S30463, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Sandoval-Pistorius SS, Hacker ML, Waters AC, Wang J, Provenza NR, de Hemptinne C, et al

Gut inflammation and barrier dysfunction may facilitate -synuclein misfolding in the enteric nervous system, with retrograde propagation via the vagus nerve ( Probiotics, prebiotics, and synbiotics are under clinical investigation as adjunct therapies to modulate gut-brain interactions and reduce systemic inflammation ( 5 Treatment challenges and therapeutic innovations Despite being the cornerstone of symptomatic management, current Parkinsons disease (PD) treatments are palliative rather than disease-modifying

Image created by author with BioRender.com The classical presentation of GHI, termed Laron syndrome (OMIM #262500), comprises severe short stature, delayed bone age, delayed tooth eruption, delayed puberty and distinctive facial features including frontal bossing, mid-facial hypoplasia and occasionally blue sclera

10.1016/j.phymed.2014.04.012 147 WangZ.DuH.PengW.YangS.FengY.OuyangH.et al (2022)