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Concurrently, TGF-1-mediated fibrous encapsulation drives joint structural remodeling and cartilage degradation ( 2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Figure 2

However, the small sample-size, the short treatment period, the absence of control groups, the lack of liver biopsy evaluation after treatment are just some of the limitations of these studies

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Mitochondrial ATP is required for the maintenance of membrane integrity in stallion spermatozoa, whereas motility requires both glycolysis and oxidative phosphorylation