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A practical workup combines symptoms, diet, medication history, whole-blood histamine, homocysteine, SAM, SAH, copper/zinc balance, pyrroles and toxic-burden clues

doi: 10.1038/onc.2015.414 201 ToskaEOsmanbeyogluHUCastelPChanCHendricksonRCElkabetsMet al

Aug 13 2021;10(8)doi:10.3390/antiox10081283
In addition, the L973F substitution does not fully explain all the differences between IR and IGF1R signaling
