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This often does not take place until months after the patient's onset of symptoms and numerous referrals have been made

Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA et al (2014) Antioxidants accelerate lung cancer progression in mice

The Warburg effect, observed in tumor cells, involves the conversion of glycolytic pyruvate to lactate instead of further catabolism through the TCA cycle, leading to reduced energy production per mole of glucose (Manoj et al., 2022