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Furthermore, in animal models, glycyrrhizin has been shown to inhibit the activation of hepatic stellate cells (HSCs) and induce their apoptosis by blocking NF-B nuclear translocation, thereby preventing liver fibrosis ( 3.1.2 Interference with arachidonic acid cascade In an lipopolysaccharide (LPS)-stimulated macrophage model, researchers found that MgIG inhibited the activation of PLA 2 in LPS-stimulated macrophages ( 2 (PLA 2 ) is the key initiating enzyme of the arachidonic acid cascade, responsible for catalyzing the hydrolysis of membrane phospholipids to release arachidonic acid

When the animal surfaces, reperfusion makes oxygen readily available for the electron transport chain, which leads to increased production of reactive oxygen species and risk of oxidative damage

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To mitigate these risks, researchers explored various strategies, including cobalt-60 irradiation (208)