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The most recent observational retrospective cohort study, which included 134 patients who received nutritional support for an average of 10 days before and after surgery, reached similar conclusions

Namely, a major index of protein oxidation is the introduction of carbonyl groups to the protein, and the dipole moment of the C=O bond leads to rearrangement of the protein conformation to allow the polarity of the carbonyl bonds to be close to the surface of the protein and in contact with the cells various aqueous phases

In fact, while not all the studies have shown efficacy, I was particularly impressed by this meta analysis of 5 studies which found NAC has value in treating depression
