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One important observation was that the iron atom contained in the heme group moves in response to oxygenation status: in the deoxygenated state the heme iron is coplanar with the porphyrin ring, but when bound to oxygen the heme iron is displaced from the planar ring (3) (FIGURE 1)

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Second, to delineate the personalized SCAN, we used an iterative precision functional mapping approach, as previously reported in detail 114,115,116