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Neuroinflammation 18 , 129 (2021)

To date, it has been observed that the treatment with this kind of antitumor agents causes ROS generation, mitochondrial dysfunction (including frataxin deficiency, mitochondrial DNA damage and defective components of ETC), loss in antioxidant enzymes, ion channels disturbances and nerve tissue damage (protein carbonylation and lipid peroxidation) (Areti et al., 2017)

Tumor volumes were measured along 3 orthogonal axes ( a , b , and c ) and calculated as abc /2 every 24 days

Typically, Fe 3+ is internalized and carried to endosomes by means of the transferrin receptor (Kawabata, 2019)