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investigated the eryptosis rate in healthy RBCs treated with different concentrations of IL-6, IL-1, urea, and p -cresol, comparable to their plasma levels in CKD patients, at different time points, and evaluated the cytotoxic effect on RBCs by an in vitro setting

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Inclusion of BSO also substantially downregulated cholesterol and FA biosynthesis genes, aligning with previous studies involving GSH depletion 47 (Fig