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Under physiological conditions, controlled LPO participates in redox signaling and barrier homeostasis by modulating the composition of epidermal lipids, including ceramides and free fatty acids [23]

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L-glutathione, the primary skin-brightening active, shifts melanin production from eumelanin (brown-black pigmentation) toward pheomelanin (lighter pigmentation) by reducing the oxidative environment required for eumelanin synthesis and by inhibiting tyrosinase the rate-limiting enzyme in the melanogenesis pathway

Topiramate prevents oxaliplatin-related axonal hyperexcitability and oxaliplatin induced peripheral neurotoxicity