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Excessive intake of garlic oil can also increase the risk of miscarriage in pregnant women

L-asparaginase associated with high ASNS expression may be overcome by the use of ASNS inhibitor as reported in an in vitro study of L-asparaginase resistance leukemia cell line [89]

The risk of virilization (development of masculine characteristics) requires careful compound selection and dosing, but does not preclude beneficial use of these agents

Growing Life cycle Annual Harvested parts Leaves Light requirements Full sun, Partial shade Soil Medium (loam), Well-drained Soil pH 6.6 7.3 (Neutral) Growing habitat Temperate climates Planting time Early spring, Late summer, Fall Plant spacing average 0.1 m (0.30 ft) Potential insect pests Aphids, Slugs, Leafminers Potential diseases Leaf spot, Rust, Anthracnose, Damping-off, Downy mildew Because of its specific temperature and moisture requirements, spinach can be a moderately difficult plant to grow