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2012;23(8):1187 to 1208

However, it does block IL-1-beta surface binding to T cells and inhibits hyperalgesic effects of IL-1-beta in vivo, suggesting alternative signaling mechanisms that researchers continue to investigate

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The liver stores B12, and these stores can last a significant time (up to several years for non-deficient individuals), but when they are depleted, it takes consistent input to rebuild and maintain them
