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Early research shows that MOTS-c may improve insulin sensitivity, support fat loss, boost exercise capacity, reduce inflammation, and help slow age-related muscle loss

Microneedling creates temporary micro-channels in the skin, and applying a glycol-containing serum through compromised skin introduces those solvents more directly into tissue than a standard topical application would

High levels of homocysteine are associated with an increased risk of developing cardiovascular disease

Anyway, the fact that IGF-I redistribute among extravascular IGFBPs after passing the endothelium is likely to affect the local tissue bioavailability even more