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Moreover, given that dopamine agonist treatment in PD is limited by their intolerable side effects and diminished effectiveness over time, we selected astrocyte-specific PKM2 as a target to break this vicious cycle and found that pyridoxine can dimerize PKM2 to restore GSH levels, providing neuroprotection in the MPTP mouse model beyond targeting dopamine receptors

Among bacteria, Firmicutes, Bacteroides, Proteobacteria and Actinobacteria phyla represent over 90% of the gut microbiota community [60]

The risk of schizophrenia is elevated when the level of MT-1 is reduced, probably due to the lack of metallothionein, which leads to an increased risk of oxidative damage in the body, thus raising the risk of schizophrenia [102]

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