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Or how long results persist after you stop treatment

Additional theories on the Multiple-Hit Hypothesis of MASLD detail the role of lipid and sugar metabolism, gut barrier dysfunction, and systemic inflammation as common factors in metabolic syndrome [233] MASLD/MASH, caused by non-alcohol substances, such as fructose/sucrose and Western-style high-fat diets (HFDs) (containing high ratios of pro-inflammatory omega-6 fatty acids to anti-inflammatory omega-3 fatty acids), is a hepatic manifestation of metabolic syndrome [234]

Authors' contributions HN, MR, JJ, and CM formulated the questions and contributed substantially to the design of the project

Pissios P (2017) Nicotinamide N -Methyltransferase: more than a vitamin B3 clearance enzyme