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Abbreviations LC L-carnitine TC Total carnitine TMAO Trimethylamine-N-oxide CHO Carbohydrates IGF-1 Insulin-like growth factor-1 PI3K Phosphoinositide-3-kinase Akt Protein kinase B mTOR Mammalian target of rapamycin S6K S6 kinase 4E-BP 4E-binding protein FoxO Forkhead box O MuRF-1 Muscle-specific RING finger-1 atrogin-1 Muscle atrophy F-box mRNA Messenger RNA BMI Body mass index ROS Reactive oxygen species Authors contributions Conceptualization: R.O

Therefore, determining how metabolites regulate tumor progression and the immunosuppressive state of the TME, as well as systematically elucidating the effects of metabolic networks on the functions of various microenvironmental components, is crucial for understanding the regulatory mechanisms in cancer and developing novel combination therapeutic strategies

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