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Fasting-induced adipose factor (Fiaf), adipose differentiation-related protein (Adrp) and carnitine palmitoyltransferase 1a (Cpt1a), were previously shown to be direct PPAR/ targets 28,48

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This syndrome is characterized by clinical symptoms of sickness behavior such as leaden paralysis of the limbs, hypersomnia, and hyperphagia/weight gain, while mood reactivity is unimpaired, i.e., mood brightens in response to positive events (according to DSM-5 criteria for MDD with atypical features), while still suffering from lack of concentration and higher levels of exhaustibility as in melancholic MDD [99]