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TML is then hydroxylated by 6-N-trimethyllysine dioxygenase (TMLD), which is located in the mitochondrial matrix, to form 3-hydroxy-6-N-trimethyllysine (HTML)

normalised blood glutathione and increased lymphocyte reactivity to T-cell mitogens

The study was funded largely by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. It was published December 10, 2018 in the European Heart Journal

While improvements in diet and physical activity might explain some of the overall improvement, they do not account for the differences observed between the active and placebo groups