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In the liver, feeding-induced FXR activation elevates SHP expression, which forms a complex with CREB to recruit lysine-specific demethylase 1 (LSD1) to the promoters of ATGs such as Tfeb, Ulk1 , and Atg7
Circulation 138 , 23672378 (2018)
Therefore, while animal models of TBI are invaluable for advancing our understanding and treatment of this complex condition, their relevance in clinical settings depends on careful interpretation and validation of findings in human studies
