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acknowledges funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, SCHU 2494/3-1, SCHU 2494/7-1, SCHU 2494/10-1, SCHU 2494/11-1, SFB 829, KFO 286, KFO 329, GRK 2407) and the Deutsche Krebshilfe (70112899)

Thus, oral GSH supplementation not only increases body stores of GSH but a fraction is stored as GSSG

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In fact, hydrogen peroxide can be generated directly by EGF binding to its cognate receptor (96), and overexpression of intracellular antioxidant enzymes, such as catalase, peroxiredoxins, or GPx-1, have been shown to interfere with cellular proliferation and growth factor-mediated responses by removing hydrogen peroxide essential for normal signaling responses (154, 269, 324)