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Figure 2 5.1.2 Tumor suppression by bilirubin effects on proto-oncogene/oncogene signaling pathways 5.1.2.1 B-cell lymphoma-2 The Bcl-2 protein family supervises the integrity of the cellular genome to inhibit tumor growth ( p38 and p53 downstream, ultimately leading to the increased regulation of the pro-apoptotic protein Bax and the decreased regulation of the anti-apoptotic protein Bcl-2 and phosphorylation of Bcl-xL/Bcl-2 associated death promoter (Bad) ( Bilirubin, an endogenous antioxidant, has a dramatic antitumor impact on the carcinoma of colon and rectum cell lines

Routine clinical adoption requires rigorous human trials incorporating microbiome, metabolomic, and validated sleep endpoints