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Figure 1 2.1 Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease ( 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen (32)

The cobalt in cobalamin can exist in three oxidation states identified as +1 [cob(I)alamin], +2 [cob(II)alamin], and +3 [cob(III)alamin]

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When found in their free form, both primary and secondary filters are photochemically inert, and act to dissipate UV energy (95) without the production of harmful radicals (93, 96, 97), that could induce oxidative stress (97) ( Figure 2 )