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In addition, intracellular scaffold proteins interface with the actin cytoskeleton, linking transmembrane tight junction proteins to the cytoskeleton and subsequently acting as a molecular target for tight junction dysregulation in various pathways, including the Zot and zonulin pathways, which both involve the dysregulation of tight junction proteins to induce alterations in intestinal permeability (7, 1115)

These relationships were described as those on (i) gastric mucosa and mucosal protection, following alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation