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Zantac and Pepcid)may interfere with B12 absorption after long-term use, since they lower the acidity of the stomach

REV 09/2015 This product is not eligible for Medicare or Medicaid reimbursement B-12 Compliance Injection Kit More about cyanocobalamin Check interactions Compare alternatives Pricing & coupons Reviews (31) Drug images Side effects Dosage information During pregnancy Drug class: vitamins

For patients with clinical deficiency, effective replacement therapy should lead to a normal blood count after two months of treatment, while improvement in neurologic symptoms begins within one week after initiation of therapy and is usually complete within 6 weeks to 3 months.13 For patients with an asymptomatic biochemical deficiency (ie, subclinical disease), measurement of serum B12 or MMA levels should be done 2 to 3 months after initiation of replacement therapy.12 Once metformin is started, this medication is seldom discontinued unless advanced renal impairment develops

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