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BDNF protein levels in total samples ( n = 42) were significantly negatively correlated with both standard drinks per week ( r = 0.377, p = 0.014) and alcohol use per day at time of death ( r = 0.376, p = 0.0142)

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Vegans/Vegetarians, people following restrictive diets, alcoholics, people suffering from persistent stress

Pre-clinical studies highlighted the efficacy of small molecule mimetics of BDNF, such as deoxygedunin and N-acetyl-serotonin, against AD neuropathology (Jang et al., 2010a, 2010b