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This knowledge serves as a foundation for developing novel drugs from plant sources

d , Uptake of indicated concentrations of [ 13 C 2 , 15 N]-GSH into mitochondria isolated from parental HEK-293T mitotag cells for 10 min

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Peroxynitrite is believed to inhibit electron flow at CI, CIII, and minimally at CIV via direct interaction with the complexes ( Furthermore, increased free radical production can also induce cell death via the downstream effects of oxidative damage to the respiratory chain and RNS-mediated induction of diminished mitochondrial permeability transition ( Alternatively, RNS-mediated induction of mitochondrial permeability transition may also signal (necrotic or apoptotic) cell death ( There is no doubt that NO plays a key role in the redox state
