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Research shows that elevated manganese levels enhance intracellular ROS formation, inhibit mitochondrial complexes I and II of the electron transport chain, disrupt mitochondrial function, and cause dopaminergic cell death [64]

In the papers discussion, the authors wrote: Chronoferroptosis could explain the prolonged prodromal period between initial iron accumulation and GSH depletion and eventual neuronal loss in neurodegenerative diseases, thereby defining a critical therapeutic window for early intervention before cells transition to irreversible degeneration. There may be a long stretch of time before neurons die when they are still reachable

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