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Growth hormone pathway activation (via GH peptides) increases IGF-1 stimulating chondrocyte matrix synthesis
However, DNA methylation can be reversible, mediated by the ten-eleven translocation (TET) family of DNA dioxygenases that progressively oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (147151)
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The general idea taking racehorses, for example is that the more race starts a horse has, the higher the chance that EIPH will come into play
