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In 1948, Rathbun first described the disease as hypophosphatasia in an infant, presented with severe bone loss, seizures, and low levels of alkaline phosphatase tissue and blood, who died of tonic epilepsy at 2 months of age [39]

One method of doing this is to increase the stimulation of the NRF2 pathway

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Room temperature storage: Stable for 6-12 months when sealed Keep below 25C (77F) Protect from direct sunlight Store in original packaging or wrap in foil Refrigerated storage (2-8C / 36-46F): Extends shelf life to 18-24 months Preferred for long-term storage Keep in main fridge section (not freezer, not door) Freezer storage (-20C / -4F): Maximum shelf life: 24-36 months Only for unopened sealed vials Thaw completely before reconstituting Don't repeatedly freeze and thaw Why lyophilized powder is stable: Freeze-drying removes water, which is necessary for degradation reactions