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NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

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In some embodiments, the otoprotectant is a compound of Formula (VIII) having the structure of Formula (VIIIa): In some embodiments, the otoprotectant is a compound of Formula (IX): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4