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doi: 10.1016/j.algal.2019.101576 54

Macrophages are crucial effector cells in the pathological process of RA, which can interact with T, B, and fibroblast-like synovial cells to produce large amounts of cytokines, chemokines, digestive enzymes, prostaglandins, and reactive oxygen species to accelerate bone destruction

Experimental studies focus on its potential ability to upregulate cell-building proteins and modulate inflammation markers in tissue samples

Its multi-receptor mechanism is frequently investigated in controlled laboratory environments studying glucose metabolism, energy expenditure, adipose-tissue signalling, and metabolic-efficiency pathways
