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Figure 1 2 Pathogenesis of RA RA is an inflammatory disease caused by multi-cells communication and interaction by cytokines, which result in a variety of pathological reactions ( The cell-cell contact or cytokine signals from antigen-presenting cells (APCs) (especially Dendritic cells, DC) induced the conversion of T cells, B cells, synovial fibroblasts, osteoclasts and osteoblasts

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The treatment with the test micronutrients significantly reduced the mean fasting blood Hcy from 11.91 to 8.12 Mol/L ( p = 0.003), whereas Hcy did not change in the control group (from 11.38 to 12.11 Mol/L, n.s.) with a significant difference between subjects over time ( p 30% average reduction) and to the fact that 7 out of 8 treated patients having a high Hcy at baseline recorded a value within the normal limit after treatment