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doi: 10.1016/j.jcv.2016.12.010

Taken together, these observations suggest that sexual dimorphism in METH SA-induced changes in gene expression may be secondary to sex-dependent differences in the basal levels of certain genes and proteins that might impact behavioral responses after repeated exposure to an identical substance (Cadet, 2021) or might be regulated to an identical transcription factor (Lardner et al., 2021)

10.1007/s00394-012-0408-3 46 IdeT.AzechiA.KitadeS.KunimatsuY.SuzukiN.NakajimaC.et al (2015)

Without adequate amino acid intake from external sources, such as dietary protein, the body may start breaking down muscle protein into amino acids for energy, which can slow metabolism over time