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If the 4 mg maintenance arm proves non-inferior for weight maintenance in Phase 3, researchers may be able to titrate up to a high working dose during the active weight-loss phase, then step back down to a lower 4 mg maintenance dose for the long stabilization phase

This effect may be beneficial in cancer treatment but could cause nonessential cell activation and cytokine release in nononcology applications

Testosterone replacement therapy (TRT) can reduce sperm production and temporarily impact fertility in some men, making it important to discuss family planning goals with a healthcare provider before starting treatment

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