does glutathione peroxidase contain iron Schematic representation of the ferroptosis pathway. Loss of Glutathione Peroxidase: An Antioxidant Enzyme
Description
In detail, fatty acids act as raw materials in PL-PUFA-OOH synthesized through the ACSL4-ALOX pathway, and its accumulation initiates ferroptosis, in addition, OX-LDL stimulation increased ACSL4 expression which activates ferroptosis while decreased GPX4 and GCH1 expression which inhibits ferroptosis [114]
Thus, the misuse of antibiotics, which has increased resistance, has necessitated the search for alternative therapeutic agents for combating resistant pathogens
Laukka EJ
Alba-Roth J, Muller OA, Schopohl J, von Werder K
