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Description
Chemotherapy drugs that act as P-gp substrates are pumped out of tumor cells (14,15)
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This intermediate is converted to nicotinic acid adenine dinucleotide by nicotinamide mononucleotide adenylyltransferases (NMNATs), and nicotinamide adenine dinucleotide synthase (NADSYN) catalyzes amidation to produce NAD +
These observations suggest that inhibitors of ETC complexes could present a new opportunity for cancer therapy
