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It also participates in the regulation of blood pressure, maintenance of electrolyte balance and blood pH homeostasis, as well as erythropoiesis and vitamin D maturation
MITF and its downstream genes are the main targets of TGF- in inhibiting melanogenesis 42 - 45
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In the body, IGF-1Ec/MGF expression rises in muscle and other tissue after mechanical stress or damage, where it acts as an early repair-phase signal that helps start regeneration
